HPV cervical infections and serological status in vaccinated and unvaccinated women (bibtex)
by Murall, Carmen Lía; Reyné, Bastien; Selinger, Christian; Bernat, Claire; Boué, Vanina; Grasset, Sophie; Groc, Soraya; Rahmoun, Massilva; Bender, Noemi; Bonneau, Marine; Foulongne, Vincent; Graf, Christelle; Picot, Eric; Picot, Marie-Christine; Tribout, Vincent; Waterboer, Tim; Bravo, Ignacio G; Reynes, Jacques; Segondy, Michel; Boulle, Nathalie; Alizon, Samuel
Abstract:
Understanding genital infections by Human papillomaviruses (HPVs) remains a major public health issue, especially in countries where vaccine uptake is low. We investigate HPV prevalence and antibody status in 150 women (ages 18 to 25) in Montpellier, France. At inclusion and one month later, cervical swabs, blood samples and questionnaires (for demographics and behavioural variables) were collected. Oncogenic, non-vaccine genotypes HPV51, HPV66, HPV53, and HPV52 were the most frequently detected viral genotypes overall. Vaccination status, which was well-balanced in the cohort, showed the strongest (protective) effect against HPV infections, with an associated odds ratio for alphapapillomavirus detection of 0.45 (95\% confidence interval: [0.22;0.58]). We also identified significant effects of age, number of partners, body mass index, and contraception status on HPV detection and on coinfections. Type-specific IgG serological status was also largely explained by the vaccination status. IgM seropositivity was best explained by HPV detection at inclusion only. Finally, we identify a strong significant effect of vaccination on genotype prevalence, with a striking under-representation of HPV51 in vaccinated women. Variations in HPV prevalence correlate with key demographic and behavioural variables. The cross-protective effect of the vaccine against HPV51 merits further investigation.
Reference:
Murall C. L. & 20 others (2020) HPV cervical infections and serological status in vaccinated and unvaccinated women. Vaccine.
Bibtex Entry:
@article{MURALL2020,
	title = {{HPV} cervical infections and serological status in vaccinated and unvaccinated women},
	 Bdsk-url-1 = {https://www.sciencedirect.com/science/article/pii/S0264410X20313980},
	url = {https://authors.elsevier.com/a/1c1gb,60n7dv5y},
	doi = {10.1016/j.vaccine.2020.10.078},
	abstract = {Understanding genital infections by Human papillomaviruses (HPVs) remains a major public health issue, especially in countries where vaccine uptake is low. We investigate HPV prevalence and antibody status in 150 women (ages 18 to 25) in Montpellier, France. At inclusion and one month later, cervical swabs, blood samples and questionnaires (for demographics and behavioural variables) were collected. Oncogenic, non-vaccine genotypes HPV51, HPV66, HPV53, and HPV52 were the most frequently detected viral genotypes overall. Vaccination status, which was well-balanced in the cohort, showed the strongest (protective) effect against HPV infections, with an associated odds ratio for alphapapillomavirus detection of 0.45 (95\% confidence interval: [0.22;0.58]). We also identified significant effects of age, number of partners, body mass index, and contraception status on HPV detection and on coinfections. Type-specific IgG serological status was also largely explained by the vaccination status. IgM seropositivity was best explained by HPV detection at inclusion only. Finally, we identify a strong significant effect of vaccination on genotype prevalence, with a striking under-representation of HPV51 in vaccinated women. Variations in HPV prevalence correlate with key demographic and behavioural variables. The cross-protective effect of the vaccine against HPV51 merits further investigation.},
	journal = {Vaccine},
	author = {Murall, Carmen Lía and Reyné, Bastien and Selinger, Christian and Bernat, Claire and Boué, Vanina and Grasset, Sophie and Groc, Soraya and Rahmoun, Massilva and Bender, Noemi and Bonneau, Marine and Foulongne, Vincent and Graf, Christelle and Picot, Eric and Picot, Marie-Christine and Tribout, Vincent and Waterboer, Tim and Bravo, Ignacio G and Reynes, Jacques and Segondy, Michel and Boulle, Nathalie and Alizon, Samuel},
	year = {2020},
	keywords = {HPV, Vaccination, immunity, Serology, vaccination, cohort, Acute infections, Cross-protection, Genital infections, PAPCLEAR}
}
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