by Djidjou-Demasse R, Sofonea MT., Choisy M, Alizon S
Abstract:
10 Antimicrobial efficacy is traditionally described by a single value, the minimal inhibitory concentration (MIC), which is the lowest concentration that prevents visible growth of the bacterial population. As a consequence, bacteria are classically qualitatively categorized as resistant if therapeutic concentrations are below MIC and susceptible otherwise. However, there is a continuity in the space of the bacterial resistance levels. Here, we introduce a model of within-host evolution
Reference:
Djidjou-Demasse R, Sofonea MT., Choisy M, Alizon S (2023) Within-host evolutionary dynamics of antimicrobial quantitative resistance. Mathematical Modelling of Natural Phenomena. 18: 24.
Bibtex Entry:
@article{Djidjou-DemasseEtAl2023,
title = {Within-host evolutionary dynamics of antimicrobial quantitative resistance},
url = {https://hal.science/hal-03194023v4/file/ModelIntraHote_QuantiResistance.pdf},
doi = {10.1051/mmnp/2023019},
pages = {24},
volume = {18},
Bdsk-url-1 = {https://www.mmnp-journal.org/articles/mmnp/abs/forth/mmnp220099/mmnp220099.html},
abstract = {10 Antimicrobial efficacy is traditionally described by a single value, the minimal inhibitory concentration (MIC), which is the lowest concentration that prevents visible growth of the bacterial population. As a consequence, bacteria are classically qualitatively categorized as resistant if therapeutic concentrations are below MIC and susceptible otherwise. However, there is a continuity in the space of the bacterial resistance levels. Here, we introduce a model of within-host evolution},
journal = {Mathematical Modelling of Natural Phenomena},
author = {Djidjou-Demasse, Ramsès and Sofonea, Mircea T. and Choisy, Marc and Alizon, Samuel},
year = {2023},
}